About EpigenCentral

EpigenCentral provides online analyses of epigenetic patterns related to diseases, intended for the broad biomedical community and clinical practitioners. Epigenetic disruptions play a key role in many congenital diseases, such as neurodevelopmental syndromes involving autism and intellectual disabilities. This portal consolidates some known epigenetic patterns based on existing literature and our team’s work on neurodevelopmental disorders.

User guide

If you have a genome-wide DNA methylation dataset, EpigenCentral can analyze your data for the presence of molecular patterns and biomarkers known to be associated with several diseases and potentially quantify the severity and pathogenicity of epigenetic disruptions. These may help you in your diagnostic efforts to resolve ambiguities associated with genetic disorders.

EpigenCentral aims to assist clinical researchers with the differential diagnosis of new cases and cohorts while also continuously incorporating user-submitted datasets to enhance underlying predictive models. Our goal is to bridge the gap between the research teams generating epigenetic datasets and the clinicians who can use this knowledge to make accurate and timely diagnoses.

EpigenCentral is developed in collaboration between The Centre for Computational Medicine and the Weksberg Lab at The Hospital for Sick Children in Toronto. Please send your questions or suggestions to turinsky {at} sickkids {dot} ca. We want to hear from you!

How to cite: if you make use of EpigenCentral or its methodology, please cite our paper:

Turinsky AL, Choufani S, Lu K, Liu D, Mashouri P, Min D, Weksberg R, Brudno M. EpigenCentral: Portal for DNA methylation data analysis and classification in rare diseases. Hum Mutat. 2020 Jul 5. doi: 10.1002/humu.24076. Epub ahead of print. PMID: 32623772.